When creating all of our professional supplements, the best research matters.  With each ingredient, Drs. Michael, Noah and Wanda Lee reviewed hundreds of recently published research articles to carefully select each ingredient.

We believe that you also have the right and responsibility to be educated in what is going on with your body as well as any supplement, therapy or treatment you receive.  To help you learn more, here are just a few of the most interesting articles to explore:


A Standardized WS extract significantly reduces stress related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study.

A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.

Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.

Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.

A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera.

Effects of Withania somniferain patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial study

Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.

Withania somnifera Improves Semen Quality in Stress-Related Male Fertility.

Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974.


Therapeutic effects and safety of Rhodiolarosea extract WS® 1375 in subjects with life-stress symptoms–results of an open-label study.

Multicenter, open-label, exploratory clinical trial with Rhodiola roseaextract in patients suffering from burnout symptoms

The Effects of Rhodiolarosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms.

Stress management and the role of Rhodiolarosea: a review.

A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiolarosea in the treatment of subjects with stress-related fatigue.

Rhodiolarosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.

Clinical trial of Rhodiolarosea L. extract SHR-5 in the treatment of mild to moderate depression.

A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiolarosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.

A randomized trial of two different doses of a SHR-5 Rhodiolarosea extract versus placebo and control of capacity for mental work.


GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.


Tryptophan and 5-hydroxytryptophanfor depression.

Fibromyalgia and the serotonin pathway.

Double-blind study of 5-hydroxytryptophanversus placebo in the treatment of primary fibromyalgia syndrome.

5-Hydroxytryptophanversus methysergide in the prophylaxis of migraine. Randomized clinical trial.

A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep.


Suboptimal magnesium status in the United States: are the health consequences underestimated?

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.

[Magnesium deficiency and stress: Issues of their relationship, diagnostic tests, and approaches to therapy].

[Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet].

Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice.

[Very low magnesium levels in red blood cells as a significant factor in the etiopathogenesis of borderline disorders].

Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome


Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man.

Aqueous extract of valerian reduces latency to fall asleep in man.

[Efficacy and tolerability of Baldrian versus oxazepam in non-organic and non-psychiatric insomniacs: a randomised, double-blind, clinical, comparative study].

Critical evaluation of the effect of valerian extract on sleep structure and sleep quality.

An aqueous extract of valerian influences the transport of GABA in synaptosomes.

Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo‐controlled pilot study

Valerian/lemon balm use for sleep disorders during menopause.

Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans.

Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes.


Valerian/lemon balm use for sleep disorders during menopause.

Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.

Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial.

The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleepdisorder in patients with chronic stable angina.


GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.

Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models.

The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract.

Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.