When creating these supplements, the best research matters.  With each ingredient, Drs. Michael, Noah and Wanda Lee reviewed hundreds of recently published research articles to carefully select each ingredient.

We believe that you also have the right and responsibility to be educated in what is going on with your body as well as any supplement, therapy or treatment you receive.  To help you learn more, here are just a few of the most interesting articles to explore:


A Standardized WS extract significantly reduces stress related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study.

A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.

Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.

Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.

A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera.

Effects of Withania somniferain patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial study

Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.

Withania somnifera Improves Semen Quality in Stress-Related Male Fertility.

Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974.


Therapeutic effects and safety of Rhodiolarosea extract WS® 1375 in subjects with life-stress symptoms–results of an open-label study.

Multicenter, open-label, exploratory clinical trial with Rhodiola roseaextract in patients suffering from burnout symptoms

The Effects of Rhodiolarosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms.

Stress management and the role of Rhodiolarosea: a review.

A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiolarosea in the treatment of subjects with stress-related fatigue.

Rhodiolarosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.

Clinical trial of Rhodiolarosea L. extract SHR-5 in the treatment of mild to moderate depression.

A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiolarosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.

A randomized trial of two different doses of a SHR-5 Rhodiolarosea extract versus placebo and control of capacity for mental work.



Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

Glutathione as a Marker for Human Disease

N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione


Tryptophan and 5-hydroxytryptophanfor depression.

Fibromyalgia and the serotonin pathway.

Double-blind study of 5-hydroxytryptophanversus placebo in the treatment of primary fibromyalgia syndrome.

5-Hydroxytryptophanversus methysergide in the prophylaxis of migraine. Randomized clinical trial.

A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep.


Suboptimal magnesium status in the United States: are the health consequences underestimated?

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.

[Magnesium deficiency and stress: Issues of their relationship, diagnostic tests, and approaches to therapy].

[Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet].

Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice.

[Very low magnesium levels in red blood cells as a significant factor in the etiopathogenesis of borderline disorders].

Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome


Vitamin D in acute stress and critical illness

Vitamin D and the central nervous system

Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial

The relationship between serum 25(OH)D levels and anxiety symptoms in older persons: Results from the Longitudinal Aging Study Amsterdam

Vitamin D in inflammation mitigation and role as signaling molecule

Correlation of symptoms to serum vitamin D levels?

The effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial

Association between Vitamin D Status and Premenstrual Symptoms

Association between vitamin D status and metabolic syndrome risk factors

Clinical trial of the effects of vitamin D supplementation on psychological symptoms and metabolic profiles in maintenance methadone treatment patients

Vitamin D and depression

Vitamin D in anxietyand affective disorders.

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort

Adult vitamin D deficiency exacerbates impairments caused by social stress in BALB/c and C57BL/6 mice

Vitamin D protects against diabetic nephropathy: evidence-based effectiveness and mechanism

Inhibition of endoplasmic reticulum stress and oxidative stress by vitamin D in endothelial cells

Vitamin D inhibits palmitate-induced macrophage pro-inflammatory cytokine production by targeting the MAPK pathway


Reversal of behavioral decline and neuropathology by a complex vitamin supplement involves modulation of key neurochemical stressors

Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial.

Effects of Oral Vitamin C Supplementation on Anxietyin Students: A Double-Blind, Randomized, Placebo-Controlled Trial.

Association between nutritional status and cognitive functioning in a healthy elderly population.

Cognitive impairment and mortality in a cohort of elderly people.

Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials.

Vitamin C lowers blood pressure and alters vascular responsiveness in salt-induced hypertension.

Role of antioxidants in generalised anxiety disorder and depression

Vitamin C impacts anxiety-like behavior and stress-induced anorexia relative to social environment in SMP30/GNL knockout mice

Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise

Vitamin C in Stem Cell Reprogramming and Cancer

Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells.


Role of antioxidants in generalised anxiety disorder and depression

[The effect of stress on blood levels of vitamin A and E in piglets].

Vitamin A, infection, and immune function.


Reversal of behavioral decline and neuropathology by a complex vitamin supplement involves modulation of key neurochemical stressors

Low intake of B-vitamins is associated with poor adolescent mental health and behaviour

Do patterns of nutrient intake predict self-reported anxiety, depression and psychological distress in adults? SEPAHAN study

The effect of methylated vitamin B complex on depressive and anxietysymptoms and quality of life in adults with depression.

The effects of vitamin B on the immune/cytokine network and their involvement in depression

Analgesic and Neuroprotective Effects of B Vitamins

Association between nutritional status and cognitive functioning in a healthy elderly population.

Cognitive decline: A vitamin B perspective